> For example, an average man with an average woman's level of testosterone will experience a MUCH higher level depression, listlessness, and sexual disinterest than the average woman experiences.
Is this true even if they were to have an average woman's level of estrogen? It may be that the brain needs either set of hormones to work effectively, and doesn't work well when lacking both (of course, gender transition HRT aims for this, but pretty much all undergoing it are trans and so aren't a good indication of average reaction to hormones for their chromosomal sex. And a cis person undergoing the same HRT isn't likely to enjoy the process)
Is this true even if they were to have an average woman's level of estrogen? It may be that the brain needs either set of hormones to work effectively, and doesn't work well when lacking both (of course, gender transition HRT aims for this, but pretty much all undergoing it are trans and so aren't a good indication of average reaction to hormones for their chromosomal sex. And a cis person undergoing the same HRT isn't likely to enjoy the process)