I encourage you to reflect on your prior statements.
> I'm leery of any claim that "this one neat trick will be the end of this entire class of disease."
Sure, I overspoke. My usage of the word eliminate is strong - there are always edge cases in biology. And I should've been more specific with my language and specified ASCVD instead of the more broad "heart disease". That would, kinda by definition, scope what I'm talking about to fatty deposits. However, I think we're deep in pedantic territory and I hope you forgive me my excess. I didn't mean to enter "one neat trick' territory, though I can see how I came off that way.
> chagas
I'm also a layman and accept there are gaping holes in my knowledge, which is why I asked you a genuine question: "What do you suggest is the mechanism of action behind that?". My interpretation is that high levels of chronic inflammation leads to endothelial damage which leads to the formation of cholesterol plaques as the immune system attempts to fix the damage it caused. I'm going to assume here that "Infection chewing on the heart is a problem." means you think the parasite literally eats holes in blood vessels? I don't know what you think, which is why I asked. If you know the pathogenesis of heart disease with Chagas, I'd love to learn.
> I am leery of any plan to globally suppress any class of molecule.
A fair concern. I would note that healthy children have an LDL of 23.8 mg/dl https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529694/ and they manage to supply their greedy brains. Note too that circulating (blood) cholesterol is not "global" cholesterol:
> The body has four distinct “pools” of cholesterol, in which tissues have regulatory mechanisms to maintain their respective homeostasis. In order of size, these pools of cholesterol consist of: peripheral tissues, red blood cells, liver, and lipoproteins. It turns out that the brain synthesizes its own cholesterol and does not exchange cholesterol with the other aforementioned pools, which means that cholesterol concentrations outside the brain have no direct impact on brain cholesterol. https://peterattiamd.com/does-low-cholesterol-cause-cognitiv...
I encourage you to reflect on your prior statements.
> I'm leery of any claim that "this one neat trick will be the end of this entire class of disease."
Sure, I overspoke. My usage of the word eliminate is strong - there are always edge cases in biology. And I should've been more specific with my language and specified ASCVD instead of the more broad "heart disease". That would, kinda by definition, scope what I'm talking about to fatty deposits. However, I think we're deep in pedantic territory and I hope you forgive me my excess. I didn't mean to enter "one neat trick' territory, though I can see how I came off that way.
> chagas
I'm also a layman and accept there are gaping holes in my knowledge, which is why I asked you a genuine question: "What do you suggest is the mechanism of action behind that?". My interpretation is that high levels of chronic inflammation leads to endothelial damage which leads to the formation of cholesterol plaques as the immune system attempts to fix the damage it caused. I'm going to assume here that "Infection chewing on the heart is a problem." means you think the parasite literally eats holes in blood vessels? I don't know what you think, which is why I asked. If you know the pathogenesis of heart disease with Chagas, I'd love to learn.
> I am leery of any plan to globally suppress any class of molecule.
A fair concern. I would note that healthy children have an LDL of 23.8 mg/dl https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529694/ and they manage to supply their greedy brains. Note too that circulating (blood) cholesterol is not "global" cholesterol:
> The body has four distinct “pools” of cholesterol, in which tissues have regulatory mechanisms to maintain their respective homeostasis. In order of size, these pools of cholesterol consist of: peripheral tissues, red blood cells, liver, and lipoproteins. It turns out that the brain synthesizes its own cholesterol and does not exchange cholesterol with the other aforementioned pools, which means that cholesterol concentrations outside the brain have no direct impact on brain cholesterol. https://peterattiamd.com/does-low-cholesterol-cause-cognitiv...