Tofu, 100% peanut butter with no added oil or additive, skyr yogurt (10g of proteins for 100g for around 50kcal !), there are a lot of options
What's hard is not protein intake but to moderate carbs intake in my opinion
This is such a sad comment. Indeed, the demographic situation was known and predictable in the 80's, and for instance in France we did nothing to plan around it.
So now the young generation is expected to pay longer and longer for retirees, who have a higher median revenue and a higher standard of life than the active workforce (per all studies). There is absolutely no way I'm working until 70 to finance errors from the past without a contribution from our current retirees' wealth. There is anyway no foreseeable future with work for everyone until 70 with our current technological progress unless you want to slave everyone in bullshit jobs. All of this is madness.
This was exactly my complaint when the Dutch retirement age was raised from 65 to 67. Baby boomers, the largest generation, were about to retire, and the argument was that the younger generations weren't large enough to provide for them, so they'd have to continue working longer.
But it wasn't the baby boomers who had to work longer, it was the younger generations who had to work longer for the baby boomers to be able to retire.
At the very least tax the generous pensions of the wealthier baby boomers to provide for the poorer baby boomers.
You can't say they did nothing about it.
They actually did: make sure to restrain access to well-paying jobs with long and costly studies; make sure to regulate any way the young could get ahead by creating rules for things they never had to suffer through and make sure to increase the age of retirement as well as increase the ratio of contributions from salary.
It's all very cynical, and it's based on fundamental egoistic human behavior. Most boomers I know are proud to be egoist and very often stingy.
They all think that they can make the difference by helping their own children, but this is flawed "thinking" in a system that is profoundly collectivist.
And all this comes from the massive flaw of democracy: only numbers matter, if you are the dominant demographic, you can get whatever you want, regardless of the nefarious impacts down the line.
When people keep repeating the trope of democracy is the worst form of government expect of all the others, I laugh my ass off. It can only be so if you have a way to weigh the votes otherwise you are just ruled by the tyranny of the mob and that generally doesn't turn out nicely.
The problem has been artificially created, the ideology said that restricting personal freedom was better for everyone as a whole and we can very much observe that this was a lie of epic proportions...
Rails 8 can make you a one-person framework and a successful SaaS solo-owner. Don't really care about the declining market share imo, I love and embrace it despite its shortcomings.
AFAICT Formstack and Omnisend are marketing automation and analytics services, not automatic split testing. I got out of the marketing space a while back but I do appreciate the cross check! However it doesn't look like those products are doing exactly this.
So excited by this ! Im 30 and finally, after reading tons of papers about AS and/or inflammatory pathways it is the first time I can imagine a cure for my anlylosing spondylitis. Too bad it will take years of approval once developed. I volunteer for trials and not in the placebo group please !
I can't see the full text of the article and most of the abstract is over my head. Is AS mentioned in the paper or are you just hopeful that a similar thing could be developed for AS and other autoinflammitory diseases?
The same method very likely could work for most auto-immune conditions if they can repeat the basic method in humans. They’re essentially turning on and/or ramping up the existing self-regulation mechanism of the immune system. I’ve only read the abstract, but what I’m not sure about is their selective delivery/targeting method, as that seems the hardest part. The various regulatory pathways cells are fairly well studied for most AI conditions and the mRNA sequences for their associated receptors could be programmed readily as I understand the technology.
However, if it does work in humans it’ll be a huge leap forward for treatment of auto immune diseases. Perhaps long term, even inflammatory issues like arterial plaque, which we’re slowly realizing is formed by chronic inflammation as much as by high cholesterol. Alzheimer’s May also be largely driven by incorrect immune responses too.
I suspect the challenge will be long term mRNA suitability, e.g. if the mRNA delivery mechanisms will develop immune reactions of their own. The cost of delivering the mRNA treatments could be large too. Biologics for autoimmune conditions require self administered shots too, but don’t require deep freezer cold. Also it could increase long term cancer risks by over stimulating self-regulatory pathways.
Not sure if the full article mentions if it’s a one time shot or on going. I’m presuming ongoing dice mRNA will degrade.
Another complication with RA and AS will be the number of linked autoantigens involved. Both RA and AS likely will benefit from collagen II autoantigens but also appear to be triggered by a bunch of other autoantigens as well. Still mRNA should cope with that case better than current methods too! It’s easy to print lots of different antigens in one go.
Our bodies ard entirely capable of doing that without external mRNA. Im also interested in potential side effects when we already have an autoimmune disorder.
