The fuel is (almost) harmless, it's the fission products that make reactors dangerous. Many of those are water-soluble. Of course the fuel elements should be encased, but drinking pool water is probably not a great idea anyway.
As a long-standing supporter of Internet freedoms in Russia, I could advise you to use multiple tools at the same time, to avoid them being blocked.
What would probably work UNLESS they roll out pretty sophisticated DPI that could block by signatures and do active probing:
1. AmneziaVPN (https://amneziavpn.org) - they have the hosted option, or you could run your own on a cheap VPS (preferable). They use Xray/REALITY or a variant of Wireguard with extra padding that confuses DPIs. Should be good enough.
2. Psiphon
3. Lantern
4. Sometimes Tailscale works surprisingly well (even in Russia where they have advanced DPI systems!)
Here's a link to several Tor browser mirrors for you so you could download the VPN software itself:
Maybe it's time for ISPs to start endorsing small donations to Mozilla and others, for a good cause. But in the jacked up world we're living in, nobody would do this.
ISPs are a commodity business and can't afford to donate money. This really hits at the core of the contradiction here. People want the incredible public good of a modern web browser -- without the monopoly that can and has an incentive to pay for it.
Desloratadine (Clarinex, Aerius) is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor.
From Wikipedia:
> At very high doses, it is also an antagonist at various subtypes of the muscarinic acetylcholine receptors. This effect is not relevant for the drug's action at therapeutic doses.
Thus, it is an anticholinergic only at very high doses, and it does not readily pass the BBB, therefore drowsiness is NOT likely (probably at very high doses only). At any rate, it does not affect the CNS at therapeutic doses, so memory / cognition issues, along with drowsiness are not an issue.
FWIW "2% of Caucasians and 18% of people from African descent are desloratadine poor metabolizers.", meaning "In these people, the drug reaches threefold higher plasma concentrations at seven hours after intake, and it has a half-life of 89 hours (compared to a 27-hour half-life in normal metabolizers). Adverse effects were reported at similar rates in poor metabolizers, suggesting that it is not clinically relevant.".
I do not think that there are any definitive single nucleotide polymorphisms (SNPs) currently known to be specifically correlated with poor desloratadine metabolism.
I think perhaps the genetic variation in the enzymes involves in its metabolism like UGT2B10 and CYP2C8 may contribute to differences in metabolism. There is just no conclusive identification of specific SNPs that definitively determine poor metabolizer status. The precise genetic variants (if any) have not yet been definitively pinpointed.
For all we know, the differences may be attributable to variations in study design, sample sizes, definition of what constitutes a "poor metabolizer", and genetic heterogeneity among populations. Some reported rates of poor metabolizers vary, some studies report around 7% overall and 20% in African descent individuals, while others suggest the figures I have mentioned. There was a somewhat recent randomized study in healthy Chinese subjects, and found no statistically significant association between the UGT2B10 or CYP2C8 genotypes.
What is clear is that while genetic factors are likely involved and poor metabolizer phenotype exists for the drug, no single genetic marker has yet been found to predict poor metabolism of this drug, and there is a notable interethnic difference in desloratadine metabolism.
TL;DR: Currently there is no definitive evidence linking specific SNPs to poor desloratadine metabolism, but genetic variation in enzymes like UGT2B10 and CYP2C8 is implicated, but further research is needed.
I hope this answers your question, but the bottom line is that more research is needed. If you know something, let me know though!
Interesting, and thank you for the informative response. I have very weird reactions to cholinergic/anticholinergic drugs ranging from severe hallucinations to massive impacts to working memory. I've always figured there is something unique about that part of my biology but don't really no where to look to try and identify why.
I have weird or controversial reactions to most medications, especially psychiatric and drugs. I have no clue why. I have MS, I have brain lesions, they might play a part.
- For example nothing happened from 190 x 1 mg alprazolam + 0.5 L whiskey.
- None of the psychiatric medications worked for me (tried almost all there is, it took a long time). No pros, nor cons.
- Opiates do not cause euphoria, nor sedation for me. Without tolerance.
- The list goes on...
I have never figured out why medications affect me extremely differently from other people.
I took 5 x 50 mg DPH, nothing happened, then the next day I took it again, and I got anticholinergic toxicity. Perhaps it accumulated in this case, but yeah, it was one of the worst experiences I have had (delirium with dysphoric hallucinations, cognitive decline, memory issues). Took me months to recover. I have had auditory hallucinations for a couple of days, too.
What cholinergics and anticholinergics have you tried and what were your experiences?
Fuck. I was born and raised in Russia. And yet, I desperately wish for Russia to be nuked to shreds. Fucking wiped off the map.Made uninhabitable for centuries and left that way as a warning to future generations.
I don't even know if there will ever be anything other than tyranny. And yes, my relatives and friends are still over there... Others have become emigrants and refugees...
Fuck, sometimes I wish it all to just end. I never chose this. I and most of my circle didn't vote for this Hitler of modernity. I don't know, maybe I should have burnt myself on the Red Square? But what for?
This is what despair looks like. I am not judging - I am from Eastern Europe, and I grew up in a country still occupied by Russians. Knowing that no matter what good I do, my life might be destroyed by Russia makes me feel all kinds of feelings too. It's hard to find solace, but one thing that helps me is that there is always a choice. They can destroy my life, but it is up to me whether I choose not to be like them. We all die sooner or later, but if I spend my life on the right side of the eternal fight between good and evil, I still win.
I know I am not original, and I am probably not explaining it well, but it gives me a bit of tranquility. I hope it will help you too.
And the blight is spreading. The US have already fallen, Europe's chances are 50/50. The world is being robbed of the future that has liberty and pursuit of happiness in it — only to be replaced with "you die today, I die tomorrow" of the all-encompassing Russian prison law.
Don’t buy into the sorrow. The USA has survived almost 300 years, and has seen a lot of bad shit. Europe is just pulling itself up. And even if it all isn’t enough, neither Putin nor Trump are going to get much older, and both are too full of themselves to start building up a successor.
Have a little faith! Otherwise we’ve already lost.
Nuking Russia will not do anyone any good, even Ukrainians. Russian Empire should dissolve to constituent republics in the same way USSR did. Also they should be forced to give up nukes, it is in the long term interest of every country on Earth
I was also born in Russia. Things are bad now, but the arc of history is long. Stalin saw millions repressed under his brutal reign but was thrown immediately under the bus after his death. Non-hereditary autocracy is an inherently unstable system; we can still hope for positive change once the current crop of dictators passes away.
>I desperately wish for Russia to be nuked to shreds.
Well my ambitions extend beyond Russia. Just saying...
> I and most of my circle didn't vote for this Hitler of modernity.
One think I must say is that while you (or your generation) didn't vote, at some point in the past people collectively did vote/support or ignore. Common people are a divided, obedient lot as opposed to the oppressors who know how to gang up. As the quote goes:
'The only thing necessary for the triumph of evil is for good men to do nothing,'
If said junk was alpha- or beta-emitting, it could be enough of a danger for cancer.