Two of the best things I learned in French class (which was basically “Parisian culture of 1982” class) was that “impossible” in French meant “I don’t feel like it”, and if someone shrugged in a way where the edges of their mouth touched the top of their shoulders, you were shit out of luck with whatever you were asking for.
Off-topic but that reminds me of the quote from "Stand on Zanzibar" where 'impossible' is defined as IIRC "1) I can't be bothered or 2) I don't approve or 3) God can't be bothered"
You can log in to your CC instance however you like, including via Pro/Max. Happy just wraps it and provides remote access with a much better UI than using a phone-based terminal app.
I don’t think this quite answers the curiosity of whether starting treatment e.g. at birth would virtually eliminate morbidity, or whether it only slows the decline once it has started.
Consider that the disease typically manifests in your 30s — does this mean it would begin 4x later (and thus basically never manifest), or that your 15 year progressive decline from ~35-50 would take 4x longer (giving you a normal lifespan, albeit perhaps with some limitations in your later years)?