Hacker Newsnew | past | comments | ask | show | jobs | submit | more coderatlarge's commentslogin

“In March, the journal Nature published the discoveries of two paradigm-breaking antimicrobial compounds in as many weeks: a polyene macrolide antifungal called mandimycin and a lasso peptide antibiotic called lariocidin. Both these compounds, which use never-before-seen antimicrobial mechanisms, were found using techniques that let researchers look deep into the chemical diversity of microbes—much deeper than a typical antibiotic or antifungal screen might go.”


> When's the last time you made a motherboard purchase decision on the basis of firmware quality?

i would argue every apple macbook purchase implicitly includes this.


this reminds me of how broadcom maintains the “free” tier of vmware.


Can you explain? Is it not actually free?


there are so many non-functional websites and signups required to get to the end of the rainbow that any sane person quits well before getting to any freely distributed software, if, in fact, there still is some.


I actually can confirm that there is a bit of a software at the end of the tunnel! Got my free VMware that way. Then again, I also beat QT out of The Qt Company, so I'm pretty determent in that regard.


that’s amazing and deserves at least a blog post documenting that it is possible and how long it takes e2e…


i think people in tech are usually focused on free cash flow, aka playing around money.


Tech likes free cash flow because share based compensation isn't included in it.


is it possible to go to the iPhone app store and get an app that is essentially an ollama like model downloader and launcher?


i just spoke with a chem prof who said that a lot of phd students in the degree sign up not because they want to do science but because of the salary bump the degree provides in industry.

i guess that is a natural dynamic in our economic/belief system in which all central planning must be inherently bad so we must always pay the on-demand price instead of the bulk price and every mis-timing mistake has to cost a lifetime of being wrong afterwards…


you could for example be sampling in a country or geography that favors male over female offspring for cultural and social reasons. then you have to refine your research question to further clarify what you are really trying to estimate.


from the intro:

“This Best Current Practice document describes techniques for producing random quantities that will be resistant to attack. It recommends that future systems include hardware random number generation or provide access to existing hardware that can be used for this purpose. It suggests methods for use if such hardware is not available, and it gives some estimates of the number of random bits required for sample applications.”


this is how i furnished my grad school apartment way back when. fellow students helped carry furniture multiple blocks away.


from the linked pages:

“ Many working scientists, students, and hobbyists have wished to create their own tag-based hypertext knowledge base, but the combination of tools historically required to make this happen are extremely daunting. Both the Stacks project and Kerodon use a cluster of software called Gerby, but bitrot has set in and it is no longer possible to build its dependencies on a modern environment without significant difficulty, raising questions of longevity.“


Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: