Glutamate is fascinating! The latest and greatest hypothesis for mood, learning, etc. hot off the press. Suddenly everything targets NMDA/AMPA receptors and increases plasticity
Be very careful targeting NMDAr/AMPAr directly. I made this mistake. Those receptors are extremely prone to causing permanent damage due to excitotoxicity.
If you are willing to share more about your story, I'd love to hear it. Did you cause permanent damage? What were you using and how much? What are the symptoms like now?
Yes, it 100% caused permanent damage in me due to an interaction of the agonist with an unrelated stimulant. After years, I ultimately stumbled upon the combination of memantine+telmisartan which successfully reversed much of the damage. I still have issues with things that I cannot physically tolerate due to the leftover damage. Also, I tried other things like valproate that failed to fully reverse the damage, but caused significant permanent problems of their own. To make a long story short, use gentle safe indirect promoters for NMDA/AMPA like L-glutamine and at most phosphatidylserine, but nothing stronger or more low-level. Leave the direct agonism for the rodent studies.
What business model do we expect chrome to have? The same DOJ doesn't like Google giving Apple money for traffic acquisition. Why would that be allowed for spun-out chrome?
Why do we expect the rest of the ecosystem to remain static? What do you think Google's next move is if they sell chrome?
Who do you expect to buy Chrome? Not Facebook. Who else could and would want to?
This is a solution that has been proposed without really considering any second order effects. Or if they were considered, it was done badly (it would be easy to prove me wrong: they could just write up what they expect to happen, and it would have to be even mildly believable)
I would assume they would not want Facebook to buy it, obviously. Microsoft neither.
I do not have a solution for the business case I have to admit, but it has 60%+ market share I believe, I’m sure someone will figure out something to monetize this.
It might end up with chrome becoming a worse browser though, that’s not an unlikely outcome at all. But Internet as a whole would be better for it in my view, if google‘s grip got loosened a bit…
This is funny to me. I don't really trust Google's incentives in general, but unlike all of the social networks, Google benefits from a more open internet.
Sure, this has gotten worse over time (if Reddit is closed, goog can pay for access), but they've been a reasonable steward of the web. Chrome is good. I use it intentionally. (Generally, my devices do not come with it installed and I choose to install it)
There are lots of reasonable pieces of anti competitive behavior that we should be punishing. This one will make the internet worse for consumers
I think websites only working with chromium browsers is not making the internet better and is definitely not a more open internet.
I’m not saying they are the worse monopolists out there though, just that I find the logic of splitting chrome sound, in the interest of a more open internet.
Safari works fine?? It's web kit based and is better for both memory usage and battery life iiuc
I almost exclusively use it on my phone. I also use it on my laptop (I have chrome FF and safari but primary use safari and chrome because I prefer them)
This seems to be working as intended. Apple makes a great browser that runs great on their devices and is beautifully designed. Chrome works everywhere (that is important to Google!)
Safari is amazingly fast and energy efficient, but I really really like the total cookie protection feature of Firefox. It’s unique to Firefox and I wish it would become the standard.
What is so hard to believe? Technology evolves rapidly. I can't imagine that anyone investing big money in compute technology wouldn't have expected that.
Because that happened in a time when there were many players in the 90s each making their own GPUs for gaming purposes specifically. Compute was not even on the picture until things like CUDA and OpenCL came out.
Back in the late 90s, there was a project at SGI, called Bali, to make all their pipelines work in IEEE 32-bit floating point (they were using Intel i860 chips) so that they could do HW rendering of scenes written in Pixar's Renderman language.
Sony copied that idea for the 1st Playstation, and then folks like NVidia & 3DLabs quickly followed suit, the idea being they would enable that functionality for games like Final Fantasy.
In the early 2000s, the HPC folks realized that you could use a GPU for physics & engineering codes, and here were are 20 yrs later.
Isn't Austin a very left-leaning city? Though, to be fair, the people I know in Austin are deeply conservative Texas natives who hate the new atmosphere...
Edit: I'm missing the point, they said Texas, not Austin.
They're all left-leaning cities, but the Gerrymandering is strong in Austin, which divides it into four Congressional districts: the 10th, 21st, 25th and 35th.
Firefox mobile is its own beast. I experience a whole host of issues on it, but have never had issues with Firefox on desktop. Only reason I use FF for Android is for uBlock, but it's so unreliable I'm dying for a better option...
These days desktop and mobile is kinda joined at the hip because users expect things like tabs and history to sync. So if Firefox has many problems on mobile to the point where users are actively deterred from using it, that hurts Firefox on the desktop as well.
Indeed, the article title is a little misleading! Sleep depravation producing short-term improvements in human depression has been well known for some time. What the authors actually propose is an underlying mechanism to that improvement, in mice...
Thank you for this! I have very similar thoughts. Felt like I was going crazy each time I saw these types of conversations sparked by mention of the "repugnant" conclusion...
If anything wouldn't this argument suggest you should isolate and quantify the active ingredient? Certainly there is more variation between two espressos than, say, two 80 mg caffeine capsules.
